一、報(bào)告時(shí)間：2023年10月7日10:30

二、報(bào)告地點(diǎn)：莫干山校區(qū)生工樓C201報(bào)告廳

三、報(bào)告題目：SyntheticBiology2.0:theDawnofaNewEra

四、報(bào)告人：HuiminZhao，美國(guó)伊利諾伊厄巴納香檳分校教授

Dr.HuiminZhaoistheStevenL.MillerChairofchemicalandbiomolecularengineeringattheUniversityofIllinoisatUrbana-Champaign(UIUC),directorofNSFAIInstituteforMoleculeSynthesis(moleculemaker.org),andEditorinChiefofACSSyntheticBiology.HereceivedhisB.S.degreeinBiologyfromtheUniversityofScienceandTechnologyofChinain1992andhisPh.D.degreeinChemistryfromtheCaliforniaInstituteofTechnologyin1998undertheguidanceofNobelLaureateDr.FrancesArnold.PriortojoiningUIUCin2000,hewasaprojectleaderattheIndustrialBiotechnologyLaboratoryoftheDowChemicalCompany.Hewaspromotedtofullprofessorin2008.Dr.Zhaohasauthoredandcoauthoredover420researcharticlesandover30issuedandpendingpatentapplications.Inaddition,hehasgivenover470plenary,keynote,orinvitedlectures.Thirtysix(36)ofhisformergraduatestudentsandpostdocsbecameprofessorsorprincipalinvestigatorsaroundtheworld.Dr.ZhaoreceivednumerousresearchandteachingawardsandhonorssuchasAIChEFP&BDivisionAward,ECIEnzymeEngineeringAward,ACSMarvinJohnsonAward,andSIMBCharlesThomAward.Hisprimaryresearchinterestsareinthedevelopmentandapplicationsofsyntheticbiology,machinelearning,andlaboratoryautomationtoolstoaddresssociety’smostdauntingchallengesinhealth,energy,andsustainability.

五、報(bào)告摘要

Syntheticbiologyaimstodesignnovelorimprovedbiologicalsystemsusingengineeringprinciples,whichhasbroadapplicationsinmedical,chemical,food,andagriculturalindustries.ThankstotherapidadvancesinDNAsequencingandsynthesis,genomeediting,artificialintelligence/machinelearning(AI/ML),andlaboratoryautomationinthepasttwodecades,syntheticbiologyhasenteredanewphaseofexponentialgrowth.Inthistalk,IwillhighlightourrecentworkonthedevelopmentofabiofoundrynamedIllinoisBiologicalFoundryforAdvancedBiomanufacturing(iBioFAB)andAI/MLtoolsforsyntheticbiologyapplicationsandthecreationofenzymeswithnew-to-natureactivities.Examplesincludebutarenotlimitedto:(1)BioAutomata:aself-drivingbiofoundryforpathwayengineeringandproteinengineering,(2)ECNet:anAItoolforenzymeengineering,(3)CLEAN:anAItoolforenzymefunctionprediction,(4)FAST-RiPP&FAST-NPS:anautomatedandscalableplatformforrapiddiscoveryofbioactivenaturalproducts,and(5)engineeredphotoenzymeswithnew-to-naturereactivityforasymmetricsynthesis.